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A Comparative Wound Healing Study of Potoladi Ghrita, Jathyadi Ghrita and Positive Control on Rats

* Dr. Suhas H.D., P.G. Scholar, Department of RSBK, ALNRMAMC, Koppa
Porf. (Dr). Dinesh Kumar Mishra, HOD, Dept. of RSBK, ALNRMAMC, Koppa
Dr. Jagadeesh Maiyya, Associate Professor, Dept. of RSBK, ALNRMAMC, Koppa
*Corresponding author: [email protected]
Received on: 21-04-2022 Accepted: 5-05-2022 Corrected: 25-05-2022

Abstract: Background: Wound is known to human beings since the evolution. Learning of wound healings was result of observations of animals and nature. Disruption of integrity of skin, mucous, membranes and organ tissues due to trauma, infection or any other reasons is referred to as wound. Healing of such wounds is complex phenomenon involving physiological functions and medication at greater level.
Materials and Methods: 36 albino rats were randomly selected and they were divided in three groups named as positive control, Jathyadi ghrita and Patoladi ghrita Methods selected for the study were excision wound model and incision wound models. Assessment criteria was based on wound contraction and period of epithelization. To check the role of collagen, tensile strength was measured.
Result: The mean and standard deviation for percentage of area of wound closure were respectively noted on 4th, 8th, 12th and 16th days for Patoladi ghrita as 32.96 + 7.48, 54.40 + 14.16, 62.36 + 12.03and 77.55 + 6.33. The comparison between Patoladi ghrita and Jathyadi ghrita was not significant for 8th day and 12th day measurement.
Discussion: Tensile strength and period epithelization were observed better in Patoladi ghrita group in comparison to both Jathyadi ghrita and positive control. The component drugs of Patoladi ghrita are prominent in Thiktha, Kashaya, Katu and Madhura rasa.
Conclusion: The Patoladi ghrita has shown higher healing rate and tensile strength in comparison to Jathyadi ghrita and positive control. Positive control was having minimum in studied three groups.
Key words: Patoladi Ghritha, Jathyadi Ghritha, Vruna, Incision wound, Excision wound.