September 2022

A work published in The Lancet dated on 29th August 2022 reveals the muscle pain and weakness after statin treatment for atherosclerotic cardiovascular disease. Other studies mention various pathways for effects of statin on musculoskeletal system leading to muscle pain. Pathways include ubiquitin proteasome pathway, impaired signal transduction, abnormal fat oxidation, proteolysis, reduction in Q10 coenzyme etc. Lipid lowering effects of statin also affects peripheral nerves leading to muscle pain. Affects come in terms of disruption or disorganization of lipids of endoneurium and perineurium. These lipids are rich in linoleic acid, an important composition of sesame oil (Tila taila). Linoleic acid (n-6 PUFA) also reduces the risks of coronary heart diseases by bringing the f...

* Dr. Rajni Devi, P.G. Scholar, Department of Agada Tantra, RGGPGAC, Paprola, H.P. *Dr. Munna Lal Prajapati, Reader, Department of Agada Tantra, RGGPGAC, Paprola, H.P. * Porf. (Dr). Jaram Singh, HOD, Dept. of Agada Tantra, RGGPGAC, Paprola, H.P. Dr. Rajveer Singh, Asst. Professor, Dept. of Agada Tantra, RGGPGAC, Paprola, H.P. *Corresponding author: [email protected] Received on: 28-05-2022 Accepted: 21-06-2022 Corrected: 15-07-2022 Abstract: Background: Gunja is plant drug mentioned as main Visha among group of eight in Sthavara Visha in Sushruta Samhita as seeds of plants have toxic effects on multiple organs. Abrin and agglutinin-I are major compounds having toxic effects. Various workers have shown that the ingestion pulverized seeds causing pulmonary edem...

Month: September 2022

Editorial- September- 2022

Toxicity of Gunja (Abrus precatorius) Seeds With Special Reference to Abrin: A Review