
Editorial- September- 2022
A work published in The Lancet dated on 29th August 2022 reveals the muscle pain and weakness after statin treatment for atherosclerotic cardiovascular disease. Other studies mention various pathways for effects of statin on musculoskeletal system leading to muscle pain. Pathways include ubiquitin proteasome pathway, impaired signal transduction, abnormal fat oxidation, proteolysis, reduction in Q10 coenzyme etc. Lipid lowering effects of statin also affects peripheral nerves leading to muscle pain. Affects come in terms of disruption or disorganization of lipids of endoneurium and perineurium. These lipids are rich in linoleic acid, an important composition of sesame oil (Tila taila). Linoleic acid (n-6 PUFA) also reduces the risks of coronary heart diseases by bringing the f...