Sunday, January 24News That Matters
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Editorial

Editorial- January

Editorial- January

Editorial
Centers for Disease Control and Prevention (CDC) considers prediabetes as serious condition. It is a state of intermediate hyperglycemia where sugar level is higher than normal, but not enough high to diagnose as type 2 diabetes. Recently, a research work published in Nature Medicine identifies six sub-phenotypes for prediabetes through a cohort study. The 25 years long study included 7,000 participants from Germany and UK. The study was led by Professor Hans-Urlich Haring. The study used partitioning of variables using glucose tolerance tests, MRI-measured body fat distribution, liver fat content and genetic risk. Six different clusters of sub-phenotypes were categorized as cluster 1 to 6. Three of these clusters i.e., 1,2 and 4 are suggested to be with low risk diabetes. Participants of...
Editorial- December

Editorial- December

Editorial
A recent study published online on 9th December in Nature Communications by Peckham et al. (2020) shows gender based development of severity of COVID-19 subjected to ITU (intensive therapy unit). The study is based on meta-analysis of reports from 47 countries including 3,111,714 cases. However, study considers the equivalent risks of infection in both males and females, still it shows higher odds for males. The requirement of ITU and death is respectively observed 2.84 times higher and 1.39 times higher in males. Study highlights the differences between male and females for both innate and adaptive immune system. Earlier findings from number of animals including mammals have revealed the genetic and hormonal guidance behind the better immunity in females than male. Higher expression of T...
Editorial- November

Editorial- November

Editorial
                   Indian philosophy is based on positive thinking. Rigveda refers to positive thinking in core to improve capabilities. It further emphasizes that the person involved in good deeds experience divine happiness. Positivity in thought is directly connected to brain. Recently a study published in Psychological Science highlights the importance of positive affects with less memory decline in old ages. Positive affect is related to subjectivity experiences of joy, interest and alertness.                       Positive affect is linked to decrease in cortisol level and increase in serotonin level and dopamine level. Researches done on human and animals reveal the link of high cortisol with decreased gray matter in all brain regions. It is directly connected to neurodegeneration....
Editorial- October

Editorial- October

Editorial
The genomic structure of coronavirus is non-segmented positive strand RNA (+ssRNA) with nucleocapsid. It has single stranded genomes. It has four main structural proteins as spike glycoprotein, envelop glycoprotein, membrane glycoprotein and nucleocapsid protein. Several other accessory proteins are also present. Spike glycoprotein facilitates binding to host cells by attraction of angiotensin-converting enzyme 2 (ACE2) in lower respiratory tract in synergy with TMPRSS2 (transmembrane serine protease 2). The furin cleavage site of virus is essential for breakdown of Spike glycoprotein and it determines the entry of virus in host cells. The nucleocapsid protein is localized in endoplasmic reticulum. It is bound to nucleic acid material of the virus. It is responsible for viral genome and r...
Editorial – September

Editorial – September

Editorial
A condition with recurring signs and symptoms of indigestion is functional dyspepsia. It is common problem across the globe reported to be 11%-29.2% (Mahadeva and Goh,2006). Changing lifestyle and induction of food items with lots of acid and salts aggravates the condition. Carbonated, alcoholic and caffeinated drinks further vitiate the problems of indigestion. Charak Vimanasthana (C.Vi.) 2/3 apparently mentions about the ratio of solid and liquid food in proper quantity to avoid harmful effects raised from food. C.Vi 2/9 hints about the types of food and drinks to be taken. Even anger, stress, anxiety, confusion, fear etc. are suggested to avoid during intake of food and drinks. Anger, stress and anxiety are related with increased cortisol. Gastric acid secretion increases due to increa...
Editorial – August

Editorial – August

Editorial
Sexuality is not only limited to progeny, but is a beautiful way for social intimacy recognized for human life. It is highly influenced by culture. Sexual expression sway around beliefs, values, attitudes and behaviors generated from culture. Still, physiology and psychology are pivotal. Psychologically, stress, depression, anxiety, relationship problems, feeling of guilt, concerns about performance etc. are common problem in both male and female. These all are responsible for the frazzled status mind resulting in diminishing libido. American’s Psychiatric Association’s Diagnostic and Statistical Manual Fourth Edition (DSM-IV) considers arousal, not only as a physical genital phenomenon, but subjective excitement/pleasure. Reasons are obvious that psychological treatment of depression inc...
Editorial- July

Editorial- July

Editorial
Srimadbhagwad Gita clearly mentions anger as door for hell. Even Charak Samhita refers anger to be avoided by wise people. Modern medical science deals it as feeling of annoyance, displeasure and hostility. Excessive anger is related with many of psychological problems including attention deficit disorder, conduct disorder, psychotic disorder, personality disorder, bipolar disorder etc. Bipolar disorder is easily identified with extreme shifts in mood. It may be resulted from changing neurochemicals due to various reasons viz., altered brain structure, genetics, environmental etc. A study has observed structural brain abnormalities in prefrontal cortex while another study finds family history responsible for affective disorder. Limbic and extrapyramidal circuit is involved in this case fo...
Editorial – June

Editorial – June

Editorial
Anaplastic lymphoma kinase (ALK) gene is capable of mutations of actual DNA codes by forming a fusion gene. It is already related with various types carcinoma. Recently, it was published online on https://www.news-medical.net/ (26th May) that ALK gene variant facilitates the resistance to weight gain. It means lacking or masking of ALK variants may lead to new frontiers against the obesity. The study was focused on identification of genetic susceptibility to obesity to physiologically healthy thin individuals based on BMI. The study was done on Drosophila and mice. In Drosphila, decrease in triglyceride levels were observed after deleting the RNAi mediated ALK. In mice, marked resistance to diet and leptin-mutation induced obesity was observed after deletion of ALK. The mechanism is sugge...
Editorial- May

Editorial- May

Editorial
The International Committee on Taxonomy of Viruses (ICTV) announced on 11 February 2020 the name of new virus as ‘severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). On same date, World Health Organization declared the disease name as COVID-19. Millions of people are affected by COVID-19 across the globe. Study shows the shape of coronavirus virions as spherical to pleomorphic, means assumed to take various shapes. Projected glycoproteins are present as studs on envelop of this virus. These glycoproteins are responsible for attachment with host cells through Aminopeptidase-N and Sialic acid containing receptors. These glycoproteins carry antigens like 229E and OC43. Impacts of these antigens are totally different; however mechanism of interference with genome is having similarit...
Editorial- April

Editorial- April

Editorial
Immunity means adequate biological defense to fight untoward invasion to keep body in balanced state. It is barrier or eliminator of many of pathogens entering in normal physiological bodies. It may be innate or adaptive. Innate is non-specific mechanism of defense which works immediately coming in contact of antigen. While adaptive one is antigen-specific defense working through recognition of specified antigen. Genes play an important role in immunity development through guiding the specific function of body and that affects immunity. Gene expression is related to roadmap of regulatory networks in immune cells. Studies indicate that transcriptional regulation is associated with control of gene expression in various immune cells, both adaptive and innate. RNA polymerases are receiving si...